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Article

Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target.

Genome research - 1 Sept 2017

Jo Myungjin, Chung Ah Young, Yachie Nozomu, Seo Minchul, Jeon Hyejin, Nam Youngpyo, Seo Yeojin, Kim Eunmi, Zhong Quan, Vidal Marc, Park Hae Chul, Roth Frederick P, Suk Kyoungho

Abstract excerpt

To understand disease mechanisms, a large-scale analysis of human-yeast genetic interactions was performed. Of 1305 human disease genes assayed, 20 genes exhibited strong toxicity in yeast. Human-yeast genetic interactions were identified by en masse transformation of the human disease genes into a pool of 4653 homozygous diploid yeast deletion mutants with unique barcode sequences, followed by multiplexed...

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Identifiers

PMID: 28596290
DOI: 10.1101/gr.211649.116
PMCID: PMC5580709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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