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Article

A map of directional genetic interactions in a metazoan cell.

eLife - 6 Mar 2015

Fischer Bernd, Sandmann Thomas, Horn Thomas, Billmann Maximilian, Chaudhary Varun, Huber Wolfgang, Boutros Michael

Abstract excerpt

Gene-gene interactions shape complex phenotypes and modify the effects of mutations during development and disease. The effects of statistical gene-gene interactions on phenotypes have been used to assign genes to functional modules. However, directional, epistatic interactions, which reflect regulatory relationships between genes, have been challenging to map at large-scale. Here, we used combinatorial RNA...

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Identifiers

PMID: 25748138
DOI: 10.7554/eLife.05464
PMCID: PMC4384530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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