Article

The cyclin-G associated kinase (GAK) is a novel mitotic kinase and therapeutic target in diffuse large B-cell lymphoma

2024-10-24

Abstract excerpt

New drug targets are needed for diffuse large B-cell lymphoma (DLBCL), the most common lymphoma subtype, to enable enable development better treatments for patients not cured by standard care. We conducted a phenotypic screen of kinase inhibitors and identified the cyclin G-associated kinase (GAK) as a tumor-selective target. Though GAK is previously described primarily as a participant in membrane trafficking, we...

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Identifiers and source

Literature Corpus work: 31fd8345-aee6-5e8b-a103-1fa517bd59ef
DOI: 10.1101/2024.10.21.619489

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