Article

Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillance

2023-01-20

Abstract excerpt

The frontline therapy R-CHOP for patients with diffuse large B-cell lymphoma (DLBCL) has remained unchanged for two decades despite numerous phase III clinical trials investigating new alternatives. Multiple large studies have uncovered genetic subtypes of DLBCL enabling a targeted approach. To further pave the way for precision oncology, we perform genome-wide CRISPR screening to uncover the cellular response to...

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Literature Corpus work: 8509cb5c-5319-58e0-b02c-3c3a1fac0da8
DOI: 10.1101/2023.01.19.524713

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Resistance to vincristine in cancerous B-cells by disruption of p53-dependent mitotic surveillanceDOI 10.1101/2023.01.19.524713Read

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