Article

Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome

2024-08-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Angelman syndrome (AS), a severe neurodevelopmental disorder resulting from the loss of the maternal <italic>UBE3A</italic> gene, is marked by changes in the brain's white matter (WM). The extent of WM abnormalities seems to correlate with the severity of clinical symptoms, but these deficits are still not well characterized or understood. This study provides the...

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Literature Corpus work: 72e3d3e0-5668-5eb4-9752-008b57f53636
DOI: 10.21203/rs.3.rs-4681861/v1

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