Article

Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

2022-04-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Human intestinal epithelial organoids (IEO) are a powerful tool to model major aspects of intestinal development, health and diseases, as patient derived cultures retain many features found in-vivo . A necessary aspect of the organoid model is the requirement to expand cultures in-vitro through several rounds of passaging. This is of concern, as the passaging of cel...

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Literature Corpus work: 31a19cf8-25a8-51f9-87c8-2a6642beedca
DOI: 10.1101/2022.04.25.489354

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