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Article

Culture-Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

1 Jan 2022

Abstract excerpt

BACKGROUND & AIMS: Human intestinal epithelial organoids (IEOs) are a powerful tool to model major aspects of intestinal development, health, and diseases because patient-derived cultures retain many features found in vivo. A necessary aspect of the organoid model is the requirement to expand cultures in vitro through several rounds of passaging. This is of concern because the passaging of cells has been shown to...

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PMID: 36038072
DOI: 10.1016/j.jcmgh.2022.08.008

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