Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

doi:10.1038/s41467-020-17458-0

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Article

Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature communications - 17 Jul 2020

Kim Tae-Min, Yang In Seok, Seung Byung-Joon, Lee Sejoon, Kim Dohyun, Ha Yoo-Jin, Seo Mi-Kyoung, Kim Ka-Kyung, Kim Hyun Seok, Cheong Jae-Ho, Sur Jung-Hyang, Nam Hojung, Kim Sangwoo

Abstract excerpt

Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%),...

Topics

Animals
Biomarkers, Tumor
Breast
Breast Neoplasms
Carcinogenesis
Class I Phosphatidylinositol 3-Kinases
Cohort Studies
DNA Copy Number Variations
DNA Mutational Analysis
Datasets as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dogs

Epithelial-Mesenchymal Transition

Female

Gene Expression Regulation, Neoplastic

Humans

Mammary Glands, Animal

Mammary Neoplasms, Animal

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 32680987
DOI: 10.1038/s41467-020-17458-0
PMCID: PMC7367841

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