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Article

Cross-species oncogenic signatures of breast cancer in canine mammary tumors.

Nature communications - 17 Jul 2020

Kim Tae-Min, Yang In Seok, Seung Byung-Joon, Lee Sejoon, Kim Dohyun, Ha Yoo-Jin, Seo Mi-Kyoung, Kim Ka-Kyung, Kim Hyun Seok, Cheong Jae-Ho, Sur Jung-Hyang, Nam Hojung, Kim Sangwoo

Abstract excerpt

Genomic and precision medicine research has afforded notable advances in human cancer treatment, yet applicability to other species remains uncertain. Through whole-exome and transcriptome analyses of 191 spontaneous canine mammary tumors (CMTs) that exhibit the archetypal features of human breast cancers, we found a striking resemblance of genomic characteristics including frequent PIK3CA mutations (43.1%),...

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Identifiers

PMID: 32680987
DOI: 10.1038/s41467-020-17458-0
PMCID: PMC7367841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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