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Article

Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma

20 Aug 2019

Abstract excerpt

Abstract Purpose: Naturally occurring primary canine lung cancers share clinicopathologic features with human lung cancers in never-smokers, but the genetic underpinnings of canine lung cancer are unknown. We have charted the genomic landscape of canine lung cancer and performed functional characterization of novel, recurrent HER2 (ERBB2) mutations occurring in canine pulmonary adenocarcinoma (cPAC). Experimental...

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PMID: 31431454
DOI: 10.1158/1078-0432.ccr-19-1145

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