Article

Single-Cell Profiling of HDAC Inhibitor-Induced EBV Lytic Heterogeneity Defines Abortive and Refractory States in B Lymphoblasts

2025-10-09

Abstract excerpt

<h4>ABSTRACT</h4> Epstein-Barr virus (EBV) is associated with multiple malignancies including Burkitt lymphoma (BL), Hodgkin’s lymphomas, nasopharyngeal carcinomas (NPC), and gastric cancers. Canonically, EBV positive tumors display latent gene expression programs that are difficult to target pharmacologically. To overcome this hurdle, lytic reactivation therapies have been developed based on HDAC inhibition with...

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Literature Corpus work: 319acc0b-e518-5b1b-bdc6-790580e0b319
DOI: 10.1101/2025.10.09.681362

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