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Epstein–Barr virus latency type and spontaneous reactivation predict lytic induction levels

16 Apr 2016

Abstract excerpt

The human Epstein-Barr virus (EBV) evades the immune system by entering a transcriptionally latent phase in B cells. EBV in tumor cells expresses distinct patterns of genes referred to as latency types. Viruses in tumor cells also display varying levels of lytic transcription resulting from spontaneous reactivation out of latency. We measured this dynamic range of lytic transcription with RNA deep sequencing and...

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PMID: 27091426
DOI: 10.1016/j.bbrc.2016.04.070

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