Rel+ macrophages disturbing cardiac niche contributes to cardiac dysfunction following sepsis.

Abstract excerpt

BACKGROUND: Cardiac dysfunction is a major cause of high mortality in sepsis. A well-organized cardiac microenvironment, consisting of cardiomyocytes and non-cardiomyocytes, is essential for maintaining heart function. The mechanism is still unclear. METHODS: Single-cell and single-nuclei RNA sequencing of the left ventricular tissues from cecal ligation and puncture-induced septic shock mice models were used to...

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