Article

Kat2a-Mediated Histone Lactylation Promotes Ferroptosis and Inflammation in Sepsis-Associated Lung Injury

2025-12-04

Abstract excerpt

<title>Abstract</title> <p>The mortality rate of sepsis-associated acute lung injury (ALI) remains high, with its core mechanisms closely linked to macrophage-mediated inflammation and ferroptosis. Lipopolysaccharide (LPS), a key factor in Gram-negative bacterial infections, can activate epigenetic modifications and induce ferroptosis. However, the role of Kat2a-mediated histone lactylation (H3K18la) in ALI and i...

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Literature Corpus work: 07b94130-3350-5cd8-94b9-f2555d1952be
DOI: 10.21203/rs.3.rs-8069085/v1

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