Article

Human Alveolar Macrophage Function is Impaired in Tuberculosis Contacts With Diabetes

2024-11-28

Abstract excerpt

<title>Abstract</title> <p>Type 2 diabetes (T2D) increases susceptibility to tuberculosis (TB) with the underlying mechanisms remaining unknown. To determine whether immune dysfunction in the lung contributes to TB susceptibility, we obtained paired human alveolar macrophages (HAMs) and monocyte-derived macrophages (MDMs) from TB-exposed individuals with/without T2D. Upon infection with Mycobacterium tuberculosis...

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Literature Corpus work: 3195b415-fac7-580a-91f5-4f58555711b0
DOI: 10.21203/rs.3.rs-5489046/v1

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