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Article

Glycaemic burden disrupts innate immunity in TB by modulating CD206 expression and macrophage antimicrobial responses.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2026

Arora Alisha, Panda Sudhasini, Luthra Kalpana, Mohan Anant, Gupta Yashdeep, Kumar Umesh, Singh Archana

Abstract excerpt

Tuberculosis (TB) and diabetes mellitus (DM) represent a growing dual global health burden, with chronic hyperglycaemia recognized as a major modifier of host immunity against Mycobacterium tuberculosis (Mtb). Macrophages, central to pathogen recognition, phagocytosis, antigen presentation, and intracellular killing, may be particularly vulnerable to diabetic metabolic dysregulation. This study evaluated...

Read the complete abstract on PubMed

Topics

Humans
Immunity, Innate
Macrophages
Phagocytosis
Mycobacterium tuberculosis
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Lectins, C-Type

Mannose-Binding Lectins

Receptors, Cell Surface

Mannose Receptor

Tuberculosis, Pulmonary

Diabetes Mellitus, Type 2

Case-Control Studies

Middle Aged

Blood Glucose

Adult

Phenotype

Source

Identifiers

PMID: 42574826
DOI: 10.1016/j.tube.2026.102799

Genes

CD80
CD86
MARCO
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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