Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.

Frontiers in immunology - 1 Jan 2024

Ssekamatte Phillip, Nabatanzi Rose, Sitenda Diana, Nakibuule Marjorie, Bagaya Bernard Ssentalo, Kibirige Davis, Kyazze Andrew Peter, Kateete David Patrick, Sande Obondo James, van Crevel Reinout, Cose Stephen, Biraro Irene Andia

Abstract excerpt

Background: Efforts to eradicate tuberculosis (TB) are threatened by diabetes mellitus (DM), which confers a 3-fold increase in the risk of TB disease. The changes in the memory phenotypes and functional profiles of Mycobacterium tuberculosis (Mtb)-specific T cells in latent TB infection (LTBI)-DM participants remain poorly characterised. We, therefore, assessed the effect of DM on T-cell phenotype and function...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Cytokines

Share to Immunologic Memory

Share to Latent Tuberculosis

Share to Mycobacterium tuberculosis

Share to Uganda

Source

Open in PubMed Open full text

Identifiers

PMID: 39430752
DOI: 10.3389/fimmu.2024.1480739
PMCID: PMC11486641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.PMID 39430752Read ↗

Profiling leucocyte subsets in tuberculosis-diabetes co-morbidity.Semantic proximity Read ↗

Type 2 diabetes mellitus is associated with altered CD8(+) T and natural killer cell function in pulmonary tuberculosis.Semantic proximity Read ↗

Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progressionSemantic proximity Read ↗

Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis.Semantic proximity Read ↗

Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus.Semantic proximity Read ↗

Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review.Semantic proximity Read ↗

Analysis of the Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells to Discriminate Latent from Active Tuberculosis in HIV-Uninfected and HIV-Infected IndividualsSemantic proximity Read ↗

Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbiditySemantic proximity Read ↗

Latent Tuberculosis infection in high TB disease burden countries dysregulates cellular and immunological profiles which is further enhanced with uncontrolled hyperglycemiaSemantic proximity Read ↗

Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection.Semantic proximity Read ↗

Human Alveolar Macrophage Function is Impaired in Tuberculosis Contacts With DiabetesSemantic proximity Read ↗

Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.