Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis.

doi:10.1590/0074-02760170326

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Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis.

Memorias do Instituto Oswaldo Cruz - 19 Feb 2018

Lopez-Lopez Nallely, Martinez Ana Gabriela Ramos, Garcia-Hernandez Mariana Haydee, Hernandez-Pando Rogelio, Castañeda-Delgado Julio Enrique, Lugo-Villarino Geanncarlo, Cougoule Céline, Neyrolles Olivier, Rivas-Santiago Bruno, Valtierra-Alvarado Monica Alejandra, Rubio-Caceres Marisela, Enciso-Moreno Jose Antonio, Serrano Carmen Judith

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) is a risk factor for the development of tuberculosis (TB), although the associated mechanisms are not known. OBJECTIVES: To study the association between T2D and the basal phenotype of macrophages, and their immune response to Mycobacterium tuberculosis (Mtb) infection. METHODS: We evaluated the influence of T2D on the response of monocyte-derived macrophages (MDM) to Mtb in...

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PMID: 29513874
DOI: 10.1590/0074-02760170326
PMCID: PMC5851047

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