Article

Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity

2022-02-08

Abstract excerpt

<h4>Background</h4> People with diabetes are more likely to develop tuberculosis (TB) and to have poor TB treatment outcomes than those without. We previously showed that blood transcriptomes in people with TB-diabetes (TB-DM) co-morbidity have excessive inflammatory and reduced interferon responses at TB diagnosis. It is unknown whether this persists through treatment, potentially underlying adverse outcomes. <h4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9fc9ee7-7cb6-58be-9d86-83ee90e19f78
DOI: 10.1101/2022.02.07.22269422

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidityDOI 10.1101/2022.02.07.22269422Read

The effects of co-morbidities on blood transcriptomes in tuberculosis patients before and during treatmentSemantic proximity Read

Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatmentSemantic proximity Read

Latent Tuberculosis infection in high TB disease burden countries dysregulates cellular and immunological profiles which is further enhanced with uncontrolled hyperglycemiaSemantic proximity Read

Diabetes mellitus is associated with a shared hyper-inflammatory immune response in melioidosis and tuberculosis patients: an observational case-control studySemantic proximity Read

Host-directed therapy in diabetes and tuberculosis comorbidity toward global tuberculosis eliminationSemantic proximity Read

Whole blood vs serum-derived exosomes for host and pathogen-specific tuberculosis biomarker identification: RNA-seq based machine learning approachSemantic proximity Read

Host susceptibility to tuberculosis: insights from a longitudinal study of gene expression in diabetes.Semantic proximity Read

Neutrophil-primed immunopathology in poorly-controlled diabetes worsens matrix destruction in pulmonary tuberculosisSemantic proximity Read

Type 2 diabetes mellitus associated microRNAs in tuberculosis susceptibility: a systematic review and bioinformatic analysis.Semantic proximity Read

Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review.Semantic proximity Read

Identification of host gene expression biomarkers for tuberculosisSemantic proximity Read

Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genesSemantic proximity Read