Article

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

2022-10-30

Abstract excerpt

Blood vessels play a critical role in pancreatic islet health and function, yet current culture methods to generate islet organoids from human pluripotent stem cells (SC-islets) lack a vascular component. Here, we engineered 3D vascularized SC-islet organoids by assembling SC-islet cells, human primary endothelial cells (ECs) and fibroblasts both in a non-perfused model and a microfluidic device with perfused vess...

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Literature Corpus work: 318f4e9d-67ce-5ba2-b77c-60e2a637b32e
DOI: 10.1101/2022.10.28.513298

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