Article

AAV Assembled Capsids Are Produced in Cells Blocked from Cell Cycle Progression.

2025-08-23

Abstract excerpt

Adeno-associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 10 11 and 10 15 viral genomes (vg), requiring an average of 10 to 30 L production/dose. As a consequence, production costs are prohibitive for most indications. Our recent studies revealed that o...

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Literature Corpus work: 317e9d83-5895-51d8-bd83-856aeb7cd2a5
DOI: 10.22541/au.175593247.76283357/v1

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