Article

Targeting Multiple Immune Checkpoints with a Single Therapy: Implications for Treating Central Nervous System Tumors

2026-02-14

Abstract excerpt

<h4>Background</h4> Immune checkpoint inhibition has transformed cancer therapy; however, many patients fail to respond to single-agent blockade, and combination strategies are often limited by toxicity. Central nervous system tumors exploit multiple immunosuppressive pathways, including the CD200 and PD-1/PD-L1 axis to evade anti-tumor immunity and support tumor aggressiveness. <h4>Methods</h4> We investigated...

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Literature Corpus work: 317aa5d2-81e9-5863-80c0-11115ce77764
DOI: 10.64898/2026.02.10.26345679

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