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Coinhibitory Pathways in Immunotherapy for Cancer

1 Mar 2016

Abstract excerpt

The immune system is capable of recognizing tumors and eliminates many early malignant cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is immunosuppressive. Immune responses are regulated by a number of immunological checkpoints that promote protective immunity and maintain tolerance. T cell coinhibitory pathways restrict the strength and duration of immune responses, thereby...

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PMID: 26927206
DOI: 10.1146/annurev-immunol-032414-112049

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