Article

Early sodium channel blocker use improves seizures and neurodevelopment in <i>KCNQ2</i> -related disorders

2026-02-14

Abstract excerpt

<h4>Background</h4> Pathogenic KCNQ2 variants are the most common genetic cause of neonatal-onset epilepsies, with phenotypes ranging from self-limited (familial) neonatal epilepsy (SeL(F)NE) to severe developmental and epileptic encephalopathy (KCNQ2-DEE). Sodium channel blockers (SCBs) have shown promise for seizure control in these disorders, but their impact on neurodevelopmental outcomes and possible relati...

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Literature Corpus work: 62040d88-0251-54eb-8895-0b46491a0eae
DOI: 10.64898/2026.02.10.26345394

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