Article

A dynamical model of TGF- <i>β</i> activation in asthmatic airways

2021-03-29

Abstract excerpt

Excessive activation of the regulatory cytokine transforming growth factor β (TGF- β ) via contraction of airway smooth muscle (ASM) is associated with the development of asthma. In this study, we develop an ordinary differential equation model that describes the change in density of the key airway wall constituents, ASM and extracellular matrix (ECM), and their interplay with subcellular signalling pathways lea...

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Identifiers and source

Literature Corpus work: 31583d17-d895-5526-8f85-439ff2b96294
DOI: 10.1101/2021.03.28.437380

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