Article
Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function.
Pulmonary pharmacology & therapeutics - 1 Feb 2013
Yeganeh Behzad, Mukherjee Subhendu, Moir Lyn M, Kumawat Kuldeep, Kashani Hessam H, Bagchi Rushita A, Baarsma Hoeke A, Gosens Reinoud, Ghavami Saeid
Abstract excerpt
The airway smooth muscle (ASM) plays an important role in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). ASM cells express a wide range of receptors involved in contraction, growth, matrix protein production and the secretion of cytokines and chemokines. Transforming growth factor beta (TGF-β) is one of the major players in determining the structural and functional abnormalities...
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