Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling the role of TGF-β in regulation of the Th17 phenotype in the LPS-driven immune system.

Bulletin of mathematical biology - 1 May 2014

Lee Seongwon, Hwang Hyung Ju, Kim Yangjin

Abstract excerpt

Airway exposure levels of lipopolysaccharide (LPS) are known to determine type I versus type II helper T cell induced experimental asthma. While low doses of LPS derive Th2 inflammatory responses, high (and/or intermediate) LPS levels induce Th1- or Th17-dominant responses. The present paper develops a mathematical model of the phenotypic switches among three Th phenotypes (Th1, Th2, and Th17) in response to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Computer Simulation
Share to Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Immunological

Share to Th1 Cells

Share to Th17 Cells

Share to Th2 Cells

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 24610093
DOI: 10.1007/s11538-014-9946-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling the role of TGF-β in regulation of the Th17 phenotype in the LPS-driven immune system.PMID 24610093Read ↗

Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation.Semantic proximity Read ↗

Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activationSemantic proximity Read ↗

A robust model to describe the differentiation of T-helper cells.Semantic proximity Read ↗

A dynamical model of TGF- <i>β</i> activation in asthmatic airwaysSemantic proximity Read ↗

A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide.Semantic proximity Read ↗

Constraint-based network model of pathogen–immune system interactionsSemantic proximity Read ↗

Systems modeling of molecular mechanisms controlling cytokine-driven CD4+ T cell differentiation and phenotype plasticity.Semantic proximity Read ↗

Interleukin-17 cytokine signalling in patients with asthma.Semantic proximity Read ↗

A systems model for immune cell interactions unravels the mechanism of inflammation in human skin.Semantic proximity Read ↗

Implementation of a regulatory gene network to simulate the TH1/2 differentiation in an agent-based model of hypersensitivity reactionsSemantic proximity Read ↗

Tipping-point transition from transient to persistent inflammation in pancreatic isletsSemantic proximity Read ↗

Influence of an Allergen-Specific Th17 Response on Remodeling of the Airways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.