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Article

A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling.

Biomechanics and modeling in mechanobiology - 1 Oct 2018

Hill Michael R, Philp Christopher J, Billington Charlotte K, Tatler Amanda L, Johnson Simon R, O'Dea Reuben D, Brook Bindi S

Abstract excerpt

Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better understanding of their inter-dependence, we develop a mechanochemical morphoelastic model of the airway wall accounting for local volume changes in airway smooth muscle (ASM) and extracellular matrix in response to transient...

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Share to Airway Remodeling
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mechanotransduction, Cellular

Share to Muscle Contraction

Share to Muscle, Smooth

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Source

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Identifiers

PMID: 29968161
DOI: 10.1007/s10237-018-1037-4
PMCID: PMC6154265

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