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Article

Biophysical and biological characterization of hairpin and molecular beacon RNase H active antisense oligonucleotides.

ACS chemical biology - 15 May 2015

Østergaard Michael E, Thomas George, Koller Erich, Southwell Amber L, Hayden Michael R, Seth Punit P

Abstract excerpt

Antisense oligonucleotides (ASOs) are single stranded, backbone modified nucleic acids, which mediate cleavage of complementary RNA by directing RNase H cleavage in cell culture and in animals. It has generally been accepted that the single stranded state in conjunction with the phosphorothioate modified backbone is necessary for cellular uptake and transport to the active compartment. Herein, we examine the...

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PMID: 25654188
DOI: 10.1021/cb500880f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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