Article

Evaluation of polygenic score for hypertrophic cardiomyopathy in the general population and across clinical settings

2023-03-16

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is an important cause of morbidity and mortality, with rare pathogenic variants found in about a third of cases (sarcomere-positive). Large-scale genome-wide association studies (GWAS) demonstrate that common genetic variation contributes substantially to HCM risk. Here, we derive polygenic scores (PGS) from HCM GWAS, and multi-trait analysis of GWAS incorporating genetically-corr...

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Literature Corpus work: 2c93bc30-7634-5531-9b4b-5a035812db9b
DOI: 10.1101/2023.03.14.23286621

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