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Stress Hormones as a Convergent, Druggable Neuroendocrine Checkpoint in Breast Cancer: Sympathetic β-Adrenergic and HPA–Glucocorticoid Signaling Converge to Drive CD8⁺/NK Exhaustion and Immunotherapy Resistance

2026-07-30

Abstract excerpt

Chronic psychological stress is common among patients with breast cancer and has been linked to poorer outcomes, yet how it weakens antitumor immunity is still incompletely defined. Stress acts through two neuroendocrine arms. The sympathetic nervous system releases catecholamines that signal via β-adrenergic receptors, and the hypothalamic–pituitary–adrenal axis releases glucocorticoids that signal via the glucoc...

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Literature Corpus work: 312a8149-1111-5040-b419-10b4f48cca44
DOI: 10.20944/preprints202607.2188.v1

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Stress Hormones as a Convergent, Druggable Neuroendocrine Checkpoint in Breast Cancer: Sympathetic β-Adrenergic and HPA–Glucocorticoid Signaling Converge to Drive CD8⁺/NK Exhaustion and Immunotherapy ResistanceDOI 10.20944/preprints202607.2188.v1Read

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