Article

Psychosocial Determinants of Immunotherapy Response Through Chronic Inflammation and Immune Senescence

2026-01-30

Abstract excerpt

Despite revolutionary successes, 60-70% of cancer patients fail to respond to immune checkpoint inhibitors and CAR-T cell therapies, even when tumors harbor predictive biomarkers. We propose "immune biography"—the cumulative encoding of lifetime psychosocial stress in immune system function—as a critical missing variable explaining therapeutic resistance. Chronic stress operates through three neuroendocrine pathwa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bcd049a6-f6c8-5da3-bb37-a76fe7d84619
DOI: 10.20944/preprints202601.2322.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Psychosocial Determinants of Immunotherapy Response Through Chronic Inflammation and Immune SenescenceDOI 10.20944/preprints202601.2322.v1Read

Chronic Adrenergic Stress Contributes to Metabolic Dysfunction and an Exhausted Phenotype in T Cells in the Tumor Microenvironment.Semantic proximity Read

Stress Hormones as a Convergent, Druggable Neuroendocrine Checkpoint in Breast Cancer: Sympathetic β-Adrenergic and HPA–Glucocorticoid Signaling Converge to Drive CD8⁺/NK Exhaustion and Immunotherapy ResistanceSemantic proximity Read

Chronic stress: a fourth etiology in tumorigenesis?Semantic proximity Read

The cell stress and immunity cycle in cancer: Toward next generation of cancer immunotherapySemantic proximity Read

Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle ChangesSemantic proximity Read

Stress Proteins and ImmunologySemantic proximity Read

Macrophages at the Crossroads of Chronic Stress and CancerSemantic proximity Read

Profiling an integrated network of cellular senescence and immune resilience measures in natural aging: a prospective multi-cohort studySemantic proximity Read

Single-cell transcriptomics yield insights into the stress-immune interplay and inform disease riskSemantic proximity Read

Lifestyle intervention is associated with attenuation of ER stress/inflammation and enhancement of naive immune cell identity in older adults with metabolic diseaseSemantic proximity Read

Accelerated telomere shortening in response to life stressSemantic proximity Read

Stress, chronic inflammation, and emotional and physical well-being: Concurrent effects and chronic sequelaeSemantic proximity Read