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Article

Chronic Adrenergic Stress Contributes to Metabolic Dysfunction and an Exhausted Phenotype in T Cells in the Tumor Microenvironment.

Cancer immunology research - 1 Jun 2021

Qiao Guanxi, Chen Minhui, Mohammadpour Hemn, MacDonald Cameron R, Bucsek Mark J, Hylander Bonnie L, Barbi Joseph J, Repasky Elizabeth A

Abstract excerpt

Metabolic dysfunction and exhaustion in tumor-infiltrating T cells have been linked to ineffectual antitumor immunity and the failure of immune checkpoint inhibitor therapy. We report here that chronic stress plays a previously unrecognized role in regulating the state of T cells in the tumor microenvironment (TME). Using two mouse tumor models, we found that blocking chronic adrenergic stress signaling using the...

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Source

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Identifiers

PMID: 33762351
DOI: 10.1158/2326-6066.CIR-20-0445
PMCID: PMC8355045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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