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Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors.

Breast (Edinburgh, Scotland) - 1 Apr 2012

Fernández-de-Las-Peñas César, Cantarero-Villanueva Irene, Fernández-Lao Carolina, Ambite-Quesada Silvia, Díaz-Rodríguez Lourdes, Rivas-Martínez Inés, del Moral-Avila Rosario, Arroyo-Morales Manuel

Abstract excerpt

Stress can play an important role in development of cancer-related fatigue (CRF) by activating the hypothalamic-pituitary-adrenal (HPA) axis, the sympathetic nervous system (SNS), and altering the immune system. This study examined the influence of catechol-O-methyltransferase (COMT) Val158Met genotypes on salivary markers of HPA axis (cortisol), SNS (α-amylase) and immune (IgA) systems, as well as on CRF in...

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Identifiers

PMID: 21974969
DOI: 10.1016/j.breast.2011.09.012

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors.PMID 21974969Read ↗

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