Article

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis

2025-12-05

Abstract excerpt

Multiple sclerosis (MS) occurs when the central nervous system (CNS) is damaged by misguided adaptive immune responses, likely caused by a combination of environmental factors in genetically susceptible individuals. A known prerequisite for disease is Epstein-Barr virus (EBV) infection, and previous studies have demonstrated elevated Epstein-Barr virus nuclear antigen 1 (EBNA1) antibodies which cross-react with th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3123fe87-fb63-59f5-b9ce-e1f75df9aba9
DOI: 10.64898/2025.12.04.692416

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple SclerosisDOI 10.64898/2025.12.04.692416Read

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis PathogenesisSemantic proximity Read

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus associationSemantic proximity Read

Antigen-resolved remodeling of EBV-specific CD8⁺ T cell immunity in multiple sclerosisSemantic proximity Read

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patientsSemantic proximity Read

Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis.Semantic proximity Read

OCA-B promotes pathogenic maturation of stem-like CD4 <sup>+</sup> T cells and autoimmune demyelinationSemantic proximity Read

Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosisSemantic proximity Read

Immunoregulatory programs in anti‐N‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysisSemantic proximity Read

Linking myelin and Epstein-Barr virus specific immune responses in multiple sclerosis: insights from integrated public T cell receptor repertoiresSemantic proximity Read

Turncoat antibodies unmasked in a model of autoimmune demyelination: from biology to therapySemantic proximity Read

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosisSemantic proximity Read

Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.Semantic proximity Read