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Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties

2022-07-15

Abstract excerpt

The novel severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) and its emerging variants continue to pose a global health emergency. Like most coronaviruses, SARS-CoV-2 replication depends on programmed ribosomal frameshifting (PRF), which, due to its conserved nature, represents a promising antiviral target. Here, we employ a microscale thermophoresis (MST) assay to screen two diverse in-house libra...

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Literature Corpus work: 310b3c6e-336f-5a50-a3be-e04e261c6f88
DOI: 10.2139/ssrn.4157446

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