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Article

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2026

Kim Arthur S, Ma Kevin, Reinhardt Christopher J, Lazar Daniel C, Ogasawara Daisuke, Shaw Teressa M, de la Torre Juan Carlos, Bailey Adam L, Melillo Bruno, Teijaro John R, Cravatt Benjamin F

Abstract excerpt

Emerging and reemerging viruses pose a significant threat to global health. Although direct-acting antivirals have shown success, their efficacy is limited by the rapid emergence of drug-resistant viral variants. Hence, there is an urgent need for additional broad spectrum antiviral therapeutic strategies. Here, we identify by phenotypic screening a set of stereochemically defined photoreactive small molecules...

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Share to COVID-19
Share to Frameshifting, Ribosomal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41604266
DOI: 10.1073/pnas.2524108123
PMCID: PMC12867696

Genes

ETF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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