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Article

Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma.

Journal of hypertension - 1 Sept 2012

Murthy Meena, Azizan Elena A B, Brown Morris J, O'Shaughnessy Kevin M

Abstract excerpt

OBJECTIVE: Adrenal aldosterone-producing adenomas (APAs) are an increasingly recognized cause of primary aldosteronism, and somatic mutations within the KCNJ5 gene encoding an inwardly rectifying K(+) channel (also called GIRK4 or Kir3.4) have been identified by several groups including our own. We identified the previously noted G151R and L168R mutations in the region of a selectivity filter of the channel as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22743686
DOI: 10.1097/HJH.0b013e328356139f

Genes

KCNJ5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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