Article

Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

2024-04-09

Abstract excerpt

STING is an innate immune sensor that traffics across many cellular compartments to carry out its function of detecting cyclic di-nucleotides and triggering defense processes. Mutations in factors that regulate this process are often linked to STING-dependent human inflammatory disorders. To systematically identify factors involved in STING trafficking, we performed a genome-wide optical pooled screen and examined...

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Literature Corpus work: 30e3c065-4e43-5fc8-99e4-87a6838a8deb
DOI: 10.1101/2024.04.07.588166

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