Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells

18 Jul 2016

Abstract excerpt

Abstract The fundamental tenet that aging is irreversible has been challenged by the development of reprogramming technology that can restore molecular and cellular age by reversing the progression of aging. The use of cells from aged individuals as sources for reprogramming or transplantation creates a major barrier in stem cell therapy with respect to cell quality and quantity. Here, we investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mitochondrial Function and Pathology
Share to Sirtuins and Resveratrol in Medicine
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27428041
DOI: 10.1002/stem.2460

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic CellsPMID 27428041Read ↗

NAD+ Metabolism in Aging and CancerSemantic proximity Read ↗

SIRT3 Reverses Aging-Associated DegenerationSemantic proximity Read ↗

NAD + supplementation prevents STING‐induced senescence in ataxia telangiectasia by improving mitophagySemantic proximity Read ↗

p16 <sup>High</sup> senescence restricts totipotent potential during somatic cell reprogrammingSemantic proximity Read ↗

Therapeutic potential of boosting NAD+ in aging and age-related diseasesSemantic proximity Read ↗

Epigenetic Reprogramming of Aging: Reversing the Clock for Regenerative MedicineSemantic proximity Read ↗

3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in miceSemantic proximity Read ↗

Research advances in the function and anti-aging effects of nicotinamide mononucleotideSemantic proximity Read ↗

Nuclear DNA damage as a direct cause of aging.Semantic proximity Read ↗

Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in CancerSemantic proximity Read ↗

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2Semantic proximity Read ↗

Bidirectional modulation of aging-associated cellular phenotypes by mitochondrial genome replacementSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.