Article
Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny?
American journal of respiratory and critical care medicine - 15 Nov 2001
Warburton D, Tefft D, Mailleux A, Bellusci S, Thiery J P, Zhao J, Buckley S, Shi W, Driscoll B
Abstract excerpt
Herein we posit that modeling of the lungs during morphogenesis, repair, and regeneration is tightly coordinated by conserved stimulatory and inhibitory signaling mechanisms, including specific transcriptional factors, cytokines, peptide growth factors, proteases, and matrix elements. This evolutionary-developmental (evo-devo) functional conservation has been extended to morphogenesis of the respiratory tracheae...
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