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Article

Derived SNP alleles are used more frequently than ancestral alleles as risk-associated variants in common human diseases.

Journal of bioinformatics and computational biology - 1 Apr 2012

Gorlova Olga Y, Ying Jun, Amos Christopher I, Spitz Margaret R, Peng Bo, Gorlov Ivan P

Abstract excerpt

Evolutionary aspects of the genetic architecture of common human diseases remain enigmatic. The results of more than 200 genome-wide association studies published to date were compiled in a catalog (). We used cataloged data to determine whether derived (mutant) alleles are associated with higher risk of human disease more frequently than ancestral alleles. We placed all allelic variants into ten categories of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22809343
DOI: 10.1142/S0219720012410089
PMCID: PMC3655427

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