Article

Spatial enhancer activation determines inhibitory neuron identity

2023-01-30

Abstract excerpt

The mammalian telencephalon contains a tremendous diversity of GABAergic projection neuron and interneuron types, that originate in a germinal zone of the embryonic basal ganglia. How genetic information in this transient structure is transformed into different cell types is not yet fully understood. Using a combination of in vivo CRISPR perturbation, lineage tracing, and ChIP-seq in mice, we found that the trans...

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Literature Corpus work: 3088f45f-967d-5643-8cdf-b19bd6a876c9
DOI: 10.1101/2023.01.30.525356

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