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Article

Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity.

Molecular and cellular biology - 1 Mar 2008

Mattar Pierre, Langevin Lisa Marie, Markham Kathryn, Klenin Natalia, Shivji Salma, Zinyk Dawn, Schuurmans Carol

Abstract excerpt

Several transcription factors are essential determinants of a cortical projection neuron identity, but their mode of action (instructive versus permissive) and downstream genetic cascades remain poorly defined. Here, we demonstrate that the proneural basic helix-loop-helix (bHLH) gene Ngn2 instructs a partial cortical identity when misexpressed in ventral telencephalic progenitors, inducing ectopic marker...

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Identifiers

PMID: 18160702
DOI: 10.1128/MCB.01510-07
PMCID: PMC2258790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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