Article

Selective vulnerability of excitatory cortical neurons to ZMYND11 loss reveals cell-type-specific mechanisms of neurodevelopmental disorder risk

2026-06-19

Abstract excerpt

<h4>Summary</h4> Excitation/inhibition (E:I) imbalance is a convergent mechanism in neurodevelopmental disorders (NDDs), yet whether NDD risk genes disrupt excitatory and inhibitory neurons through shared or distinct molecular programs remains poorly understood. Using human pluripotent stem cell-derived cortical projection and medial ganglionic eminence-like inhibitory neurons, we show that loss-of-function mutat...

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Literature Corpus work: 5982924b-39bf-5050-a04c-e5625a0ae186
DOI: 10.64898/2026.06.16.732737

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Selective vulnerability of excitatory cortical neurons to ZMYND11 loss reveals cell-type-specific mechanisms of neurodevelopmental disorder riskDOI 10.64898/2026.06.16.732737Read

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