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Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity

8 Feb 2024

Abstract excerpt

BACKGROUND: Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking. METHODS: We performed shot-gun sequencing on 235 samples from 166 HF patients and 69 healthy control samples. Separate plasma samples from healthy controls (n = 53) were...

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PMID: 38331891
DOI: 10.1186/s13073-024-01296-6

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