Article

Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium

2020-04-10

Abstract excerpt

Coronavirus disease 2019 (COVID-19) outcomes vary from asymptomatic infection to death. This disparity may reflect different airway levels of the SARS-CoV-2 receptor, ACE2, and the spike protein activator, TMPRSS2. Here we explore the role of genetics and co-expression networks in regulating these genes in the airway, through the analysis of nasal airway transcriptome data from 695 children. We identify expression...

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Literature Corpus work: 30201605-0f2e-5dd4-8dae-6fe0bedd4b97
DOI: 10.1101/2020.04.09.034454

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