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Article

Airways tissue expression of type I interferons and their stimulated genes is higher in children than adults

1 Nov 2022

Abstract excerpt

There is emerging evidence that age-dependent differences in susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) correlate with stronger innate immune response in the upper respiratory tract in children compared to adults. The efficient induction of interferon (IFN) alpha and beta (α and β) signaling, and interferon-stimulated genes (ISGs) is fundamental to the host antiviral response....

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PMID: 36415751
DOI: 10.1016/j.heliyon.2022.e11724

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