Article
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium.
Nature communications - 12 Oct 2020
Sajuthi Satria P, DeFord Peter, Li Yingchun, Jackson Nathan D, Montgomery Michael T, Everman Jamie L, Rios Cydney L, Pruesse Elmar, Nolin James D, Plender Elizabeth G, Wechsler Michael E, Mak Angel C Y, Eng Celeste, Salazar Sandra, Medina Vivian, Wohlford Eric M, Huntsman Scott, Nickerson Deborah A, Germer Soren, Zody Michael C, Abecasis Gonçalo, Kang Hyun Min, Rice Kenneth M, Kumar Rajesh, Oh Sam, Rodriguez-Santana Jose, Burchard Esteban G, Seibold Max A
Abstract excerpt
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expression of these genes is important for deeper understanding of SARS-CoV-2 tropism and pathogenesis. Here we explore the role of genetics and co-expression networks in regulating these genes in the airway,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.