Article
Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.
Genome medicine - 21 Apr 2021
Kasela Silva, Ortega Victor E, Martorella Molly, Garudadri Suresh, Nguyen Jenna, Ampleford Elizabeth, Pasanen Anu, Nerella Srilaxmi, Buschur Kristina L, Barjaktarevic Igor Z, Barr R Graham, Bleecker Eugene R, Bowler Russell P, Comellas Alejandro P, Cooper Christopher B, Couper David J, Criner Gerard J, Curtis Jeffrey L, Han MeiLan K, Hansel Nadia N, Hoffman Eric A, Kaner Robert J, Krishnan Jerry A, Martinez Fernando J, McDonald Merry-Lynn N, Meyers Deborah A, Paine Robert, Peters Stephen P, Castro Mario, Denlinger Loren C, Erzurum Serpil C, Fahy John V, Israel Elliot, Jarjour Nizar N, Levy Bruce D, Li Xingnan, Moore Wendy C, Wenzel Sally E, Zein Joe, Langelier Charles, Woodruff Prescott G, Lappalainen Tuuli, Christenson Stephanie A
Abstract excerpt
BACKGROUND: The large airway epithelial barrier provides one of the first lines of defense against respiratory viruses, including SARS-CoV-2 that causes COVID-19. Substantial inter-individual variability in individual disease courses is hypothesized to be partially mediated by the differential regulation of the genes that interact with the SARS-CoV-2 virus or are involved in the subsequent host response. Here, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.