Article

Molecular unbalances between striosome and matrix compartments characterize the pathogenesis of Huntington’s disease model mouse

2025-07-24

Abstract excerpt

The pathogenesis of Huntington’s disease is still incompletely understood, despite the remarkable advances in identifying the molecular effects of the Htt mutation in this disease. When we focus on movement disorders, clinical studies offer us some hints about this issue. Human studies employing positron emission tomography have identified a reduction in phosphodiesterase 10A (PDE10A) as the earliest event in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 301823cc-6348-54ad-83dd-b92c321bc952
DOI: 10.1101/2025.07.20.665815

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular unbalances between striosome and matrix compartments characterize the pathogenesis of Huntington’s disease model mouseDOI 10.1101/2025.07.20.665815Read

Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.Semantic proximity Read

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunctionSemantic proximity Read

Developmental, neuroanatomical and cellular expression of genes causing dystoniaSemantic proximity Read

Expression analysis of Huntington disease mouse models reveals robust striatum disease signaturesSemantic proximity Read

High motivation for exercise is associated with altered chromatin regulators of monoamine receptor gene expression in the striatum of selectively bred miceSemantic proximity Read

Molecular insights into cortico-striatal miscommunications in Huntington's diseaseSemantic proximity Read

Huntington’s disease and striatal signalingSemantic proximity Read

G α olf Regulates Biochemical Signaling in Neurons Associated with Movement Control and InitiationSemantic proximity Read

A Spatiomolecular Map of the StriatumSemantic proximity Read

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor functionSemantic proximity Read

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomicsSemantic proximity Read

Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.Semantic proximity Read